Quarterly report pursuant to Section 13 or 15(d)

Equity Incentive Plans - Stock-based Compensation Expense (Details)

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Equity Incentive Plans - Stock-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Stock based compensation expense $ 29,247 $ 36,895
Research and development    
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Stock based compensation expense 26,227 34,815
Selling, general, and administrative    
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Stock based compensation expense $ 3,020 $ 2,080