Annual report pursuant to Section 13 and 15(d)

Equity Incentive Plans - Stock-based Compensation Expense (Details)

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Equity Incentive Plans - Stock-based Compensation Expense (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]      
Stock based compensation expense $ 220,058 $ 16,880 $ 28,133
Research and Development      
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]      
Stock based compensation expense 206,879 14,082 24,451
General and Administrative      
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]      
Stock based compensation expense $ 13,179 $ 2,798 $ 3,682