Quarterly report pursuant to Section 13 or 15(d)

Equity Incentive Plans - Stock-based Compensation Expense (Details)

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Equity Incentive Plans - Stock-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Stock based compensation expense $ 46,278 $ 41,543 $ 75,525 $ 78,438
Research and development        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Stock based compensation expense 41,424 39,499 67,651 74,314
Selling, general, and administrative        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Stock based compensation expense $ 4,854 $ 2,044 $ 7,874 $ 4,124